HC 030031

• Catalog No.: H115000
• CAS Number: 349085-38-7
• M. F.: C18H21N5O3
• M. W.: 355.39104
• Storage: Refrigerator, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 2-(1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-yl)-N-[4-(propan-2-yl)phenyl]acetamide
• IUPAC Traditional name: 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-isopropylphenyl)acetamide
• Synonyms: 1,2,3,6-Tetrahydro-1,3-dimethyl-N-[4-(1-methylethyl)phenyl]-2,6-dioxo-7H-purine-7-acetamide

DATABASE IDS

• CAS Number: 349085-38-7

PROPERTIES

• Apperance: White Solid
• Melting Point: 221-223°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Refrigerator, Under Inert Atmosphere

DETAILS

Description (English)

A TRPA1 (transient receptor potential) selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity.

REFERENCES

• Jordt, S., et al.: Nature, 427, 260 (2004)
• Macpherson, L., et al.: Curr. Biol., 15, 929 (2004)
• Dai, Y., et al.: J. Clin. Invest., 117, 1979 (2004)
• Doerner, J., et al.: J. Biol. Chem., 282, 13180 (2004)