GW 501516

• Catalog No.: G931500
• CAS Number: 317318-70-0
• M. F.: C21H18F3NO3S2
• M. W.: 453.4977296
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxy}acetic acid
• IUPAC Traditional name: 2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]phenoxyacetic acid
• Synonyms: GW 1516; Methyl-methyl-trifluoromethylphenyl-thiazolyl-methylsulfanyl-phenoxy-acetic Acid; 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid

DATABASE IDS

• CAS Number: 317318-70-0

PROPERTIES

• Apperance: Off-White to Pale Yellow Solid
• Melting Point: 134-136°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream.A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARδ agonist. Exhibits selectivity for PPARδ compared to PPARα

REFERENCES

• Oliver, W.R., et al.: Proc. Natl. Acad. Sci., USA, 98, 5306 (2001)
• Sznaidman, M.L., et al.: Bioorg. Med. Chem. Lett., 13, 1517 (2001)
• Wang, Y.X., et al.: Cell, 113, 159 (2001)