GSK PERK Inhibitor

• Catalog No.: G797800
• CAS Number: 1337531-89-1
• M. F.: C24H19F4N5O
• M. W.: 469.4341728
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 1-(5-{4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2,3-dihydro-1H-indol-1-yl)-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethan-1-one
• IUPAC Traditional name: 1-(5-{4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl}-2,3-dihydroindol-1-yl)-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone
• Synonyms: 3-Fluoro-GSK2606414; 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone

DATABASE IDS

• CAS Number: 1337531-89-1

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 237-240°C (dec.)
• Solubility: DMSO
• Storage Condition: Refrigerator

DETAILS

Description (English)

GSK PERK Inhibitor is an inhibitors of PERK, an important transmembrane protein of endoplasmic reticulum (ER). GSK PERK Inhibitor can be useful in the treatment of cancer, ocular diseases, and diseases associated with activated unfolded protein response p

REFERENCES

• Baltzis, D. et al.: J. Biol. Chem., 282, 31675 (2007)
• Axten, J. M.et al,: J. Med. Chem. 55(16) 7193 (2012).