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GSI-953

Catalog No. G797400 Name Toronto Research Chemicals
CAS Number 769169-27-9 Website http://www.trc-canada.com
M. F. C9H8ClF6NO3S2 Telephone +1 (416) 665-9696
M. W. 391.7381392 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Chembase ID: 169780

SYNONYMS

IUPAC name
(2S)-S-(5-chlorothiophen-2-yl)-4,4,4-trifluoro-1-hydroxy-3-(trifluoromethyl)butane-2-sulfonamido
IUPAC Traditional name
begacestat
Synonyms
5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide
GSI 953
Begacestat

DATABASE IDS

CAS Number 769169-27-9

PROPERTIES

Certificate of Analysis Download
MSDS Link Download

DETAILS

Description (English)
Begacestat (GSI-953) is a selective β-secretase inhibitor that selectively inhibits cleavage of APP over Notch. GSI-953 is used for treating diseases such as cancer in relation to prevention of intestinal secretory metaplasia.

REFERENCES

  • van Es., et al.: Nature, 435, 959 (2005)
  • Morohashi., et al.: J. Biol. Chem., 281, 1467 (2005)
  • O'Neil., et al.: Neoplasia, 107, 781 (2005)
  • Mayer, et al.: J. Med. Chem., 51, 7348 (2005)
  • Martone, et al.: J. Pharmacol. Exp. Ther., 331, 598 (2005)