α-Glucametacin-d4

• Catalog No.: G412802
• M. F.: C25H27ClN2O8
• M. W.: 518.94348

SYNONYMS

• IUPAC name: 2-{1-[4-chloro(^2H₄)benzoyl]-5-methoxy-2-methyl-1H-indol-3-yl}-N-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• IUPAC Traditional name: 2-{1-[4-chloro(^2H₄)benzoyl]-5-methoxy-2-methylindol-3-yl}-N-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• Synonyms: α-Indomethacin-d4 Glucosamide; α-Glucamethacin-d4; 2-[[[1-(4-Chlorobenzoyl-d4)-5-methoxy-2-methyl-1H-indol-3-yl]acetyl]amino]-2-deoxy-α-D-Glucopyranose; α-Glucametacine-d4

DETAILS

Description (English)

Labelled α-Glucametacin (G412800). A nonsteroidal antiinflammatory analgesic. An indomethacin conjugates with D-glucosamine was prepared for reducing ulcerogenic potency, increasing the bioavailability of indomethacin and exerting the coordinative effects

REFERENCES

• Mizuma, T., et al.: Biochem. Pharmacol., 43, 2037 (1992)
• Giraud, I., et al.: Bioconjugate Chem., 11, 212 (1992)
• Reginster, J., et al.: Lancet, 357, 251 (1992)