Genistein-2',3',5',6'-d4 (Major)

• Catalog No.: G350010
• CAS Number: 187960-08-3
• M. F.: C15H10O5
• M. W.: 270.2369
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 5,7-dihydroxy-3-[4-hydroxy(^2H₄)phenyl]-4H-chromen-4-one
• IUPAC Traditional name: 5,7-dihydroxy-3-[4-hydroxy(^2H₄)phenyl]chromen-4-one
• Synonyms: Baichanin A-d4; Bonistein-d4; GeniVida-d4; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d4; 4',5,7-Trihydroxyisoflavone-d4; Genisteol-d4; NSC 36586-d4; Prunetol-d4; Sophoricol-d4

DATABASE IDS

• CAS Number: 187960-08-3

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 290-292°C (dec.)
• Solubility: DMSO
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell prolif

REFERENCES

• Akiyama, T., et al.: J. Biol. Chem., 262, 5592 (1987)
• O'Dell, T.J., et al.: Nature, 353, 588 (1987)
• Aharonovits, O., et al.: Biochim Biophys. Acta, 1112, 181 (1987)
• Platanias, L.C., et al.: J. Biol. Chem., 267, 24053 (1987)
• Yoshida, H., et al.: Biochi