Geldanamycin

• Catalog No.: G304500
• CAS Number: 30562-34-6
• M. F.: C29H40N2O9
• M. W.: 560.6359
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (4E,6Z,8R,9S,10E,12S,13R,14R,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• IUPAC Traditional name: (4E,6Z,8R,9S,10E,12S,13R,14R,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
• Synonyms: 9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione 9-Carbamate; (+)-Geldanamycin; NSC 122750; NSC 212518

DATABASE IDS

• CAS Number: 30562-34-6

PROPERTIES

• Apperance: Yellow to Orange Solid
• Melting Point: 276-278°C
• Solubility: Chlorofom
• Solubility: DMSO
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Geldanamycin is a potent antitumor antibiotic active at nanomolar concentration against 60 cell lines.It binds specifically to the heat shock protein Hsp90 and to its endoplasmic reticulum homologue GP96, and thus interferes with conformational maturation

REFERENCES

• Supko, J.G., et al.: Cancer Chemother. Pharmacol., 36, 305 (1995)
• Chavany, C., et al.: J. Biol. Chem., 271, 4974 (1995)
• Schneider, C., et al.: Proc. Natl. Acad. Sci., 93, 14536 (1995)
• Whitesell, L., et al.: Mol. Endocrinol., 10, 705 (1995)
• Stebbins, C