Fumagillin

• Catalog No.: F862650
• CAS Number: 23110-15-8
• M. F.: C26H34O7
• M. W.: 458.54396

SYNONYMS

• IUPAC name: (2E,4E,6E,8E)-10-{[(3R,4S,5R,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy}-10-oxodeca-2,4,6,8-tetraenoic acid
• IUPAC Traditional name: (2E,4E,6E,8E)-10-{[(3R,4S,5R,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy}-10-oxodeca-2,4,6,8-tetraenoic acid
• Synonyms: Fumagillin DCH; Fumadil B; Fugillin; Fumidil; (-)-Fumagillin; Amebacilin; NSC 9168; (2E,4E,6E,8E)-2,4,6,8-Decatetraenedioic Acid 1-[(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl] Ester; 2,4,6,8-Decatetraenedioic Acid mono[4-(1,2-epoxy-1,5-dimethyl-4-hexenyl)-5-methoxy-1-oxaspiro[2.5]oct-6-yl] Ester

DATABASE IDS

• CAS Number: 23110-15-8

DETAILS

Description (English)

Fumagillin is a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an an anti-infective and antiangiogenic agent.

REFERENCES

• Molina, J.M. et al.: N. Eng. J. Med., 346, 1963 (2002)
• Hou, L. et al.: Pathol. Int., 59, 448 (2002)
• Ingber, D. et al.: Nature, 348, 555 (2002)