N-Formyl Leurosine (Vincristine Impurity G)

• Catalog No.: F700650
• CAS Number: 54022-49-0
• M. F.: C46H54N4O10
• M. W.: 822.94176
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: methyl (13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-8-formyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.0^4,^1^2.0^5,^1^0.0^1^6,^1^8]icosa-4(12),5,7,9-tetraene-13-carboxylate
• IUPAC Traditional name: methyl (1S,13S,15R,16R,18S)-13-[(1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-8-formyl-10-hydroxy-5-methoxy-10-(methoxycarbonyl)-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.0^4,^1^2.0^5,^1^0.0^1^6,^1^8]icosa-4(12),5,7,9-tetraene-13-carboxylate
• Synonyms: N-Formyl N-demethylleurosine; NSC 269419; Leuroformine; N-Demethyl-N-formylleurosine; (3'α,4'α)-4'-Deoxy-3',4'-epoxy-22-oxovincaleukoblastine; 22-Oxoleurosine; F-Leurosine; Formylleurosine; Vinformide; Vincristine Impurity G

DATABASE IDS

• CAS Number: 54022-49-0

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 200-210°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Degradation products of Vincristine. A Vinca dimer, a potent cytostatic agent. Vincristine Impurity G.

REFERENCES

• Erdelyi-Toth, V., et al.: Eur. J. Cancer, 17, 329 (1981)
• Ronai-Lukacs S; Eur. J. Drug Metab. Pharmacokinet., 7, 4 (1981)