Fluticasone 17β-Carboxylic Acid

• Catalog No.: F599490
• CAS Number: 28416-82-2
• M. F.: C21H26F2O5
• M. W.: 396.4249464
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-diene-14-carboxylic acid
• IUPAC Traditional name: (1R,2S,8S,10S,11S,13R,14R,15S,17S)-1,8-difluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-diene-14-carboxylic acid
• Synonyms: 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methylpregna-3-oxo-1,4-diene-17β-carboxylic Acid; (6α,11β,16α,17α)-6,9-Difluoro-11,17-dihydroxy-16-methyl-3-oxo-androsta-1,4-diene-17-carboxylic Acid

DATABASE IDS

• CAS Number: 28416-82-2

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 292-294°C (dec.)
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

The major metabolite of Fluticasone. Anti-inflammatory agent.

REFERENCES

• Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990)
• Mitchison, H.C., et al.: Gut, 32, 260 (1990)
• Ueno, H., et al.: J. Med. Chem., 34, 2468 (1990)
• Rachwal, S., et al.: Steroids, 63, 193 (1990)
• Phillipps, G.H., et al.: J. Med. Chem., 37, 37