N-(9-Fluorenylmethoxycarbonyl)-4',6,8,11-tetra-O-benzoyl Doxorubicin

• Catalog No.: F472435
• M. F.: C70H55NO17
• M. W.: 1182.1822

SYNONYMS

• IUPAC name: (1S,3S)-12-(benzoyloxy)-1-{[(2R,4R,5R,6R)-5-(benzoyloxy)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-6-methyloxan-2-yl]oxy}-3-[2-(benzoyloxy)acetyl]-3-hydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-5-yl benzoate
• IUPAC Traditional name: (1S,3S)-12-(benzoyloxy)-1-{[(2R,4R,5R,6R)-5-(benzoyloxy)-4-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-6-methyloxan-2-yl]oxy}-3-[2-(benzoyloxy)acetyl]-3-hydroxy-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-5-yl benzoate
• Synonyms: (8S,10S)-7,8,9,10-tetrahydro-8-hydroxy-6,11-dibenzoyloxy-8-(2-benzoyloxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-benzyloxy-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione

PROPERTIES

• Apperance: Yellow Solid
• Solubility: Dichloromethane

DETAILS

Description (English)

N-(9-Fluorenylmethoxycarbonyl) Doxorubicin (F472430) derivative. Used in the preparation of a modified Doxorubicin (ANG1007) and Etoposide (ANG1009) useful due to their brain penetration ability.

REFERENCES

• Che, C. et al.: J. Med. Chem. 53, 2814 (2010)