N-(9-Fluorenylmethoxycarbonyl) Doxorubicin

• Catalog No.: F472430
• CAS Number: 136582-53-1
• M. F.: C42H39NO13
• M. W.: 765.75796

SYNONYMS

• IUPAC name: 9H-fluoren-9-ylmethyl N-[(2S,3S,4S,6S)-3-hydroxy-2-methyl-6-{[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl]oxy}oxan-4-yl]carbamate
• IUPAC Traditional name: 9H-fluoren-9-ylmethyl N-[(2S,3S,4S,6S)-3-hydroxy-2-methyl-6-{[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-2,4-dihydro-1H-tetracen-1-yl]oxy}oxan-4-yl]carbamate
• Synonyms: (8S,10S)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-10-[[2,3,6-trideoxy-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione

DATABASE IDS

• CAS Number: 136582-53-1

PROPERTIES

• Apperance: Red Solid
• Solubility: Dichloromethane

DETAILS

Description (English)

Used in the preparation of a modified Doxorubicin (ANG1007) and Etoposide (ANG1009), useful due to their brain penetration ability.

REFERENCES

• Che, C. et al.: J. Med. Chem. 53, 2814 (2010)