FK-506-13C,D2 (Major)

• Catalog No.: F370002
• M. F.: C44H69NO12
• M. W.: 805.01081484
• Storage: -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25R,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3S,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-[(3-^1^3C,3,3-^2H₂)prop-2-en-1-yl]-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• IUPAC Traditional name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25R,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3S,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-[(3-^1^3C,3,3-^2H₂)prop-2-en-1-yl]-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• Synonyms: Advagraf-13C,D2; FR 900506-13C,D2; L 679934-13C,D2; Tacrolimus-13C,D2; Tsukubaenolide-13C,D2; Fujimycin-13C,D2; Prograf-13C,D2; Protopic-13C,D2; TacroBell-13C,D2

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 90-92°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A labelled immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum

REFERENCES

• Asano, K., et al.: In Vivo, 10, 537 (1996)
• McCall, E., et al.: Circ. Res., 79, 1110 (1996)
• Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996)
• Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996)
• Knoll, G.A., et al.: Brit. Med. J., 318, 1104 (1