FK-506 (Tacrolimus)

• Catalog No.: F370000
• CAS Number: 104987-11-3
• M. F.: C44H69NO12
• M. W.: 804.01816
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25R,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3S,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• IUPAC Traditional name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25R,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3S,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-(prop-2-en-1-yl)-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• Synonyms: Protopic; Fujimycin; Tsukubaenolide; Tacrolimus; FR 900506; Advagraf; L 679934; Prograf; TacroBell

DATABASE IDS

• CAS Number: 104987-11-3

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 125-129°C
• Solubility: Acetone
• Solubility: Chloroform
• Solubility: DMSO
• Solubility: Ether
• Solubility: Ethanol
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 rel

REFERENCES

• Asano, K., et al.: In Vivo, 10, 537 (1996)
• McCall, E., et al.: Circ. Res., 79, 1110 (1996)
• Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996)
• Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996)
• Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318,