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Fialuridine 5'-Monophosphate

Catalog No. F335010 Name Toronto Research Chemicals
CAS Number 99891-31-3 Website http://www.trc-canada.com
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SYNONYMS

IUPAC name
{[(2R,3S,5R)-4-fluoro-3-hydroxy-5-(5-iodo-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid
IUPAC Traditional name
[(2R,3S,5R)-4-fluoro-3-hydroxy-5-(5-iodo-2,4-dioxo-3H-pyrimidin-1-yl)oxolan-2-yl]methoxyphosphonic acid
Synonyms
1-(2-Deoxy-2-fluoro-5-O-phosphono-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione

DATABASE IDS

CAS Number 99891-31-3

PROPERTIES

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DETAILS

Description (English)
Fialuridine 5’-Monophosphate (FIAUMP) is the phosphorylated derivative and major metabolite of the antiviral agent Fialuridine (F335000). Studies show that purified mammalian DNA polymerases were able to incorporate FIAUMP into the nascent DNA chain durin

REFERENCES

  • McLaren, C. et al.: Int. Cong. Ser., 667, 57 (1985)
  • Lewis, W. et al.: BIochem., 33, 14620 (1985)