Fialuridine 5'-Monophosphate

• Catalog No.: F335010
• CAS Number: 99891-31-3
• M. F.: C9H11FIN2O8P
• M. W.: 452.0688742

SYNONYMS

• IUPAC name: {[(2R,3S,5R)-4-fluoro-3-hydroxy-5-(5-iodo-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid
• IUPAC Traditional name: [(2R,3S,5R)-4-fluoro-3-hydroxy-5-(5-iodo-2,4-dioxo-3H-pyrimidin-1-yl)oxolan-2-yl]methoxyphosphonic acid
• Synonyms: 1-(2-Deoxy-2-fluoro-5-O-phosphono-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-pyrimidinedione

DATABASE IDS

• CAS Number: 99891-31-3

DETAILS

Description (English)

Fialuridine 5’-Monophosphate (FIAUMP) is the phosphorylated derivative and major metabolite of the antiviral agent Fialuridine (F335000). Studies show that purified mammalian DNA polymerases were able to incorporate FIAUMP into the nascent DNA chain durin

REFERENCES

• McLaren, C. et al.: Int. Cong. Ser., 667, 57 (1985)
• Lewis, W. et al.: BIochem., 33, 14620 (1985)