F-Amidine

• Catalog No.: F101250
• CAS Number: 877617-45-3
• M. F.: C8H15N7O2S3
• M. W.: 337.4454

SYNONYMS

• IUPAC name: (Z)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropimidamide
• IUPAC Traditional name: brolin
• Synonyms: N-[(1S)-1-(Aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]benzamide

DATABASE IDS

• CAS Number: 877617-45-3

DETAILS

Description (English)

An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for

REFERENCES

• Jones, J.E. et al.: Curr. Opin. Drug Discov. Dev., 12, 616 (2009)
• Hill, J.A. et al.: J. Immunol., 171, 538 (2009)
• Luo, Y. et al.: Biochemistry, 45, 11727 (2009)
• Knuckley, B. et al.: Biochemistry, 49, 1 (2009)
• Slack, J.L. et al.: Cell. Mol. Life Sci.,