Everolimus

• Catalog No.: E945400
• CAS Number: 159351-69-6
• M. F.: C53H83NO14
• M. W.: 958.22442
• Storage: Hygroscopic, Store under Inert atmosphere -20°C Freezer

SYNONYMS

• IUPAC name: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• IUPAC Traditional name: (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30R,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^4,^9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
• Synonyms: 42-O-(2-Hydroxy)ethyl Rapamycin; RAD 001; SDZ-RAD; XIENCE V; 40-O-(2-Hydroxyethyl)rapamycin; Afinitor; Certican; RAD

DATABASE IDS

• CAS Number: 159351-69-6

PROPERTIES

• Apperance: Off White Solid
• Melting Point: 110-115°C
• Solubility: Chloroform
• Storage Condition: Hygroscopic, Store under Inert atmosphere -20°C Freezer

DETAILS

Description (English)

Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.

REFERENCES

• Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001)
• Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001)
• Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2001)