Etoposide Phosphate

• Catalog No.: E933755
• CAS Number: 117091-64-2
• M. F.: C29H33O16P
• M. W.: 668.536481

SYNONYMS

• IUPAC name: {4-[(10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-12-oxo-4,6,13-trioxatetracyclo[7.7.0.0^3,^7.0^1^1,^1^5]hexadeca-1(9),2,7-trien-10-yl]-2,6-dimethoxyphenoxy}phosphonic acid
• IUPAC Traditional name: 4-[(10R,11R,15R,16S)-16-{[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-12-oxo-4,6,13-trioxatetracyclo[7.7.0.0^3,^7.0^1^1,^1^5]hexadeca-1(9),2,7-trien-10-yl]-2,6-dimethoxyphenoxyphosphonic acid
• Synonyms: Etoposide 4'-Phosphate; BMY 40481; Etopofos; Etopophos; [5R-[5α,5aβ,8aα,9β(R*)]]-5-[3,5-Dimethoxy-4-(phosphonooxy)phenyl]-9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one; (5R,5aR,8aR,9S)-5-[3,5-Dimethoxy-4-(phosphonooxy)phenyl]-9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

DATABASE IDS

• CAS Number: 117091-64-2

DETAILS

Description (English)

A bioequivalent prodrug of the DNA topoisomerase II inhibitor Etoposide (E933750). Antineoplastic used in the treatment of a wide variety of hematological malignancies and solid tumors.

REFERENCES

• Kaul, S. et al.: J. Clin. Pharmacol., 13, 2835 (1995)
• J. Pharmakin. Biopharmac., 24, 313 (1995)
• Brooks, D.J. et al.: Anti-Cancer Drugs, 6, 637 (1995)