4'-Ethyl-7',8'-dihydro-4'-hydroxy-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5

• Catalog No.: E917312
• M. F.: C15H17NO6
• M. W.: 307.29858

SYNONYMS

• IUPAC name: 4'-(^2H₅)ethyl-4'-hydroxy-1',3',4',7',8',10'-hexahydrospiro[1,3-dioxolane-2,6'-pyrano[3,4-f]indolizine]-3',10'-dione
• IUPAC Traditional name: 4'-(^2H₅)ethyl-4'-hydroxy-7',8'-dihydro-1'H-spiro[1,3-dioxolane-2,6'-pyrano[3,4-f]indolizine]-3',10'-dione
• Synonyms: (±)-4'-Ethyl-7',8'-dihydro-4'-hydroxy-spiro[1,3-dioxolane-2,6'(3'H)-[1H]pyrano[3,4-f]indolizine]-3',10'(4'H)-dione-d5

PROPERTIES

• Apperance: Off-white Solid
• Solubility: Dichloroform
• Solubility: Methanol

DETAILS

Description (English)

Used in the preparation of Camptothecin and Homocamptothecin derivatives, for their therapeutic use as antitumor agents.

REFERENCES

• Wani, M.C., et al.: J. Med. Chem., 29, 2358 (1986)
• Miller, K.D., et al.: Invest. New Drugs, 22, 69 (1986)
• Punt, C.J.A., et al.: Eur. J. Cancer, 40, 1332 (1986)
• Wang, J.-Q., et al.: Bioorg. Med. Chem., 13, 549 (2005)