5'-Ethylcarboxamido-2',3'-isopropylidene Adenosine

• Catalog No.: E900995
• CAS Number: 39491-53-7
• M. F.: C15H20N6O4
• M. W.: 348.3571

SYNONYMS

• IUPAC name: (3aR,4S,6R)-6-(6-amino-9H-purin-9-yl)-N-ethyl-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxole-4-carboxamide
• IUPAC Traditional name: (3aR,4S,6R)-6-(6-aminopurin-9-yl)-N-ethyl-2,2-dimethyl-tetrahydrofuro[3,4-d][1,3]dioxole-4-carboxamide
• Synonyms: 2’,3’-O-isopropylidene-NECA; 1-(6-Amino-9H-purin-9-yl)-1-deoxy-N-ethyl-2,3-O-(1-methylethylidene)-β-D-ribofuranuronamide

DATABASE IDS

• CAS Number: 39491-53-7

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 200-202°C
• Solubility: DMSO
• Solubility: Ethanol
• Solubility: Methanol

DETAILS

Description (English)

A useful template for the development of A2B adenosine receptor agonists. It was confirmed to be a full agonist in a functional assay based on the measurement of its capacity to modulate cAMP levels in CHO cells expressing the hA2B receptor.

REFERENCES

• Kemp, B., et al.: Br. J. Pharmacol., 126, 1796 (1999)
• Peyot, M., et al.: Circ. Res., 86, 76 (1999)
• Fredholm, B., et al.: Pharmacol. Rev., 53, 527 (1999)
• Zeng, D., et al.: Drug Dev. Res., 58, 405 (1999)
• Baraldi, P., et al.: J. Med. Chem., 47, 5535 (200