(R)-7-Ethyl Camptothecin

• Catalog No.: E900825
• CAS Number: 1217633-65-2
• M. F.: C22H20N2O4
• M. W.: 376.4052

SYNONYMS

• IUPAC name: (19R)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• IUPAC Traditional name: (19R)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• Synonyms: (4R)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 7-Ethyl-20(R)-camptothecin

DATABASE IDS

• CAS Number: 1217633-65-2

DETAILS

Description (English)

R-Camptothecin (CPT) derivative; a potent antineoplastic agent against drug-resistant tumors.

REFERENCES

• Brangi, M., et al.: Cancer Res., 59 5938 (1999)
• Miyake, K., et al.: Cancer Res., 59, 8 (1999)
• Bom, D., et al.: J. Med. Chem., 43, 3970 (1999)
• Gamcsik, M., et al.: Mol. Cancer Ther., 1, 11 (2001).