7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin

• Catalog No.: E899150
• CAS Number: 185304-42-1
• M. F.: C28H30N4O6
• M. W.: 518.561
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl 4-aminopiperidine-1-carboxylate
• IUPAC Traditional name: (19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl 4-aminopiperidine-1-carboxylate
• Synonyms: NPC (metabolite); RPR 132595A; 4-Amino-(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 1-Piperidinecarboxylic Acid Ester

DATABASE IDS

• CAS Number: 185304-42-1

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: >160°C (dec.)
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A major metabolite of Irinotecan.

REFERENCES

• Canal, P., et al.: J. Clin. Oncol., 14, 2688 (1996)
• Haaz, M., et al.: Cancer Res., 58, 468 (1996)
• Kehrer, D., et al.: Clin. Cancer Res., 6, 3451 (1996)
• Hanioka, N., et al.: Xenobiotica, 31, 687 (1996)
• Satoh, T., et al.: Drug Metab. Dispos., 30, 488 (2