7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin

• Catalog No.: E898900
• CAS Number: 181467-56-1
• M. F.: C33H38N4O8
• M. W.: 618.67682
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 5-{[1-({[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxy}carbonyl)piperidin-4-yl]amino}pentanoic acid
• IUPAC Traditional name: 5-{[1-({[(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-7-yl]oxy}carbonyl)piperidin-4-yl]amino}pentanoic acid
• Synonyms: 4-[(4-Carboxybutyl)amino]-1-piperidinecarboxylic Acid (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl Ester; APC; RPR 121056

DATABASE IDS

• CAS Number: 181467-56-1

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: 166-168°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A major metabolite of Irinotecan.

REFERENCES

• Canal, P., et al.: J. Clin. Oncol., 14, 2688 (1996)
• Haaz, M., et al.: Cancer Res., 58, 468 (1996)
• Kehrer, D., et al.: Clin. Cancer Res., 6, 3451 (1996)
• Hanioka, N., et al.: Xenobiotica, 31, 687 (1996)
• Satoh, T., et al.: Drug Metab. Dispos., 30, 488 (2