Estrone 3-O-Sulfamate

• Catalog No.: E889060
• CAS Number: 148672-09-7
• M. F.: C18H23NO4S
• M. W.: 349.44452
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (1S,10R,11S,15S)-15-methyl-14-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-trien-5-yl sulfamate
• IUPAC Traditional name: (1S,10R,11S,15S)-15-methyl-14-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-2,4,6-trien-5-yl sulfamate
• Synonyms: Estrone 3-Sulfamate; 3-[(Aminosulfonyl)oxy]estra-1,3,5(10)-trien-17-one; Estrone O-Sulfamate; EMATE; Estrone Sulfamate

DATABASE IDS

• CAS Number: 148672-09-7

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 195-197°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A potent inhibitor of estrone sulfatase. Inhibits estrone sulfatase >99% at 0.1uM in intact MCF-7 cells, IC50=65pM.

REFERENCES

• Woo, L.W., et al.: J. Med. Chem., 41, 1068 (1998)