Epothilone D (synthetic)

• Catalog No.: E589000
• CAS Number: 189453-10-9
• M. F.: C27H41NO5S
• M. W.: 491.68314
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (4S,7R,8S,9S,13Z)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione
• IUPAC Traditional name: (4S,7R,8S,9S,13Z)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione
• Synonyms: Epothilone D; Epo D; Desoxyepothilone B; (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione; 12,13-Desoxyepothilone B; (-)-Desoxyepothilone B; (-)-Epothilone D; 12,13-Deoxyepothilone B; KOS 862; NSC 703147

DATABASE IDS

• CAS Number: 189453-10-9

PROPERTIES

• Apperance: White Solid
• Melting Point: 63-66°C
• Solubility: Chloroform
• Solubility: DMSO
• Solubility: Ether
• Solubility: Ethyl Acetate
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumou

REFERENCES

• Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995)
• Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (1995)
• Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)