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Epothilone B (synthetic)_Molecular_structure_CAS_152044-54-7)
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Epothilone B (synthetic)

Catalog No. E588990 Name Toronto Research Chemicals
CAS Number 152044-54-7 Website http://www.trc-canada.com
M. F. C27H41NO6S Telephone +1 (416) 665-9696
M. W. 507.68254 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer, Under Inert Atmosphere Chembase ID: 168108

SYNONYMS

IUPAC name
(1S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
IUPAC Traditional name
(1S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Synonyms
(-)-Epothilone B
(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
EPO 906A
Epothilone B
EPO 906
Patupilone

DATABASE IDS

CAS Number 152044-54-7

PROPERTIES

Certificate of Analysis Download
Apperance White Powder
Melting Point 95-97°C
Solubility Chloroform
Solubility Dichloromethane
Solubility DMSO
Solubility Ethanol
Solubility Methanol
MSDS Link Download
Storage Condition -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the c

REFERENCES

  • Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995)
  • Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (1995)
  • Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)