Eplerenone-d3

• Catalog No.: E588777
• M. F.: C24H30O6
• M. W.: 414.4914

SYNONYMS

• IUPAC name: (^2H₃)methyl (2R,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^1,^1^7.0^2,^7.0^1^1,^1^5]octadecan]-6'-ene-9'-carboxylate
• IUPAC Traditional name: (^2H₃)methyl (2R,2'S,9'R,10'R,11'S,15'S,17'R)-2',15'-dimethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^1,^1^7.0^2,^7.0^1^1,^1^5]octadecan]-6'-ene-9'-carboxylate
• Synonyms: γ-Lactone 7-(Methyl-d3) Ester; (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic Acid; CGP 30083-d3; Epoxymexrenone-d3; Inspra-d3; SC-66110-d3

PROPERTIES

• Apperance: White Solid
• Melting Point: 241-243°C
• Solubility: Chloroform

DETAILS

Description (English)

Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid rece

REFERENCES

• de Gasparo, M., et al.: J. Pharmacol. Exp. Ther., 240, 650 (1987)
• Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (1987)
• Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (1987)
• Ravis, W.R., et al.: J. Clin. Pharmacol., 45, 810 (1987)