EB 47

• Catalog No.: E320300
• CAS Number: 366454-36-6
• M. F.: C24H27N9O6
• M. W.: 537.52788

SYNONYMS

• IUPAC name: 2-{4-[(2R,3R,4S,5S)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolane-2-carbonyl]piperazin-1-yl}-N-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)acetamide
• IUPAC Traditional name: 2-{4-[(2R,3R,4S,5S)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolane-2-carbonyl]piperazin-1-yl}-N-(1-oxo-2,3-dihydroisoindol-4-yl)acetamide
• Synonyms: 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide Dihydrochloride; 5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine Dihydrochloride

DATABASE IDS

• CAS Number: 366454-36-6

DETAILS

Description (English)

EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult.

REFERENCES

• Jagtap, et al.: Bioorg. Med. Chem. Lett., 14, 81 (2004)
• Gaymes, et al.: Haematologica, 94, 638 (2004)
• Ferraris, et al.: J. Med. Chem. 53, 4561 (2004)