6α,3'-p-Dihydroxy Paclitaxel

• Catalog No.: D454200
• CAS Number: 157230-10-9
• M. F.: C47H51NO16
• M. W.: 885.90494
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (1S,2S,3R,4S,7R,8S,9R,10S,12R,15S)-4,12-bis(acetyloxy)-1,8,9-trihydroxy-15-{[(2R,3S)-2-hydroxy-3-(4-hydroxyphenyl)-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^3,^1^0.0^4,^7]heptadec-13-en-2-yl benzoate
• IUPAC Traditional name: (1S,2S,3R,4S,7R,8S,9R,10S,12R,15S)-4,12-bis(acetyloxy)-1,8,9-trihydroxy-15-{[(2R,3S)-2-hydroxy-3-(4-hydroxyphenyl)-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^3,^1^0.0^4,^7]heptadec-13-en-2-yl benzoate
• Synonyms: (αR,βS)-β-(Benzoylamino)-α,4-dihydroxybenzenepropanoic Acid 6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-3,4,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester

DATABASE IDS

• CAS Number: 157230-10-9

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 191-194°C
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

The human liver metabοlite of Paclitaxel. Antitumor agent.

REFERENCES

• Harris, J., et al.: Cancer Res., 54, 4026 (1994)
• Harris, J., et al.: J. Med. Chem., 37, 706 (1994)
• Tolcher, A., et al.: J. Clin. Oncol., 14, 1173 (1994)
• Ohyama, K., et al.: Drug Metab. Dispos., 28, 1303 (1994)