(20'RS)-15',20'-Dihydro Vinorelbine Ditartarate

• Catalog No.: D450020
• M. F.: C49H62N4O14
• M. W.: 931.03498

SYNONYMS

• IUPAC name: 2,3-dihydroxybutanedioic acid methyl (1R,9R,10S,11S,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(12S,14S)-16-ethyl-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^3,^1^1.0^4,^9]octadeca-3(11),4,6,8-tetraen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
• IUPAC Traditional name: (.+-.)-tartaric acid methyl (1R,9R,10S,11S,12R,19R)-11-(acetyloxy)-12-ethyl-4-[(1S,12S,14S)-16-ethyl-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^3,^1^1.0^4,^9]octadeca-3(11),4,6,8-tetraen-12-yl]-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
• Synonyms: (2β,3β,4β,5α,12R,19α)-4-(acetyloxy)-6,7-didehydro-15-[(2S,4RS,6S,8S)-4-ethyl-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic Acid Methyl Ester Ditartarate

DETAILS

Description (English)

A dihydro derivative of the antineoplastic Vinorelbine Ditartarate (V315000). Studies show that its vinca-induced tubulin-spiraling potential is significantly correlated with cytotoxicity against L1210 cells.

REFERENCES

• Lobert, S. et al.: Biochemistry, 39, 12053 (2000)
• Jacquesy, J.: J. Fluor. Chem., 127, 1484 (2000)