Dihydro FK-506

• Catalog No.: D448950
• CAS Number: 104987-30-6
• M. F.: C44H71NO12
• M. W.: 806.03404
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25R,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3S,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-propyl-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• IUPAC Traditional name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25R,27R)-1,14-dihydroxy-12-[(1E)-1-[(1R,3S,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-23,25-dimethoxy-13,19,21,27-tetramethyl-17-propyl-11,28-dioxa-4-azatricyclo[22.3.1.0^4,^9]octacos-18-ene-2,3,10,16-tetrone
• Synonyms: Dihydro Tacrolimus; Tsukubamycin B

DATABASE IDS

• CAS Number: 104987-30-6

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 87-93°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A novel analog of FK-506 (F370000) macrocycle.

REFERENCES

• Kino, T., et al.: J. Antibiot., 40, 1249 (1987)
• Motamedi, H., et al.: J. Bacteriol., 178, 5243 (1987)
• Dai, Y., et al.: Drug Metab. Dispos., 34, 836 (1987)