Dichlorisone

• Catalog No.: D431755
• CAS Number: 7008-26-6
• M. F.: C21H26Cl2O4
• M. W.: 413.33474

SYNONYMS

• IUPAC name: (1R,2S,10S,11S,14R,15S,17S)-1,17-dichloro-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-5-one
• IUPAC Traditional name: dichlorisone
• Synonyms: 9,11β-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione; 9α,11β-Dichloro-17α,21-dihydroxypregna-1,4-diene-3,20-dione; (11β)-9,11-Dichloro-17,21-dihydroxypregna-1,4-diene-3,20-dione

DATABASE IDS

• CAS Number: 7008-26-6

DETAILS

Description (English)

Dichlorisone is a 9α,11β-dichloro corticoid. Dichlorisone has anti-antiinflammatory potency. Dichlorisone could be modifed to be used as glucocorticoid receptor agonists as well as a P-glycoprotein inhibitor.

REFERENCES

• Collins, E.J. et al.: Proc. Int. Congr. Horm. Steroids, 2, 530 (1967)
• Gruol, D.J. et al.: Cancer Res., 57, 720 (1967)