Dibenzazepine (Deshydroxy LY 411575)

• Catalog No.: D422600
• CAS Number: 209984-56-5
• M. F.: C26H23F2N3O3
• M. W.: 463.4759264
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (2S)-2-[2-(3,5-difluorophenyl)acetamido]-N-[(10S)-8-methyl-9-oxo-8-azatricyclo[9.4.0.0^2,^7]pentadeca-1(11),2(7),3,5,12,14-hexaen-10-yl]propanamide
• IUPAC Traditional name: (2S)-2-[2-(3,5-difluorophenyl)acetamido]-N-[(10S)-8-methyl-9-oxo-8-azatricyclo[9.4.0.0^2,^7]pentadeca-1(11),2(7),3,5,12,14-hexaen-10-yl]propanamide
• Synonyms: N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

DATABASE IDS

• CAS Number: 209984-56-5

PROPERTIES

• Apperance: White Solid
• Melting Point: 257-259°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A dipeptidic γ-secretase inhibitor. AntiAlzheimer agent.

REFERENCES

• Weihofen, A., et al.: Science, 296, 2215 (2002)
• Weihofen, A., et al.: J. Biol. Chem., 278, 16528 (2002)
• Kan, T., et al.: Bioorg. Med. Chem. Lett., 14, 1983 (2002)
• Krawitz, P., et al.: J. Biol. Chem., 280, 39515 (2002)
• Tomita, T., et al.: Curr. Pharm.