N-Des-t-boc-N-2-[2-methyl-1-(4-methoxyphenyl)methoxy]propyloxycarbonxyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel

• Catalog No.: D422275
• CAS Number: 154044-74-3
• M. F.: C57H63Cl6NO20
• M. W.: 1294.82282

SYNONYMS

• IUPAC name: (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-1-hydroxy-15-{[(2R,3S)-2-hydroxy-3-{[({1-[(4-methoxyphenyl)methoxy]-2-methylpropan-2-yl}oxy)carbonyl]amino}-3-phenylpropanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-9,12-bis({[(2,2,2-trichloroethoxy)carbonyl]oxy})-6-oxatetracyclo[11.3.1.0^3,^1^0.0^4,^7]heptadec-13-en-2-yl benzoate
• IUPAC Traditional name: (1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-1-hydroxy-15-{[(2R,3S)-2-hydroxy-3-{[({1-[(4-methoxyphenyl)methoxy]-2-methylpropan-2-yl}oxy)carbonyl]amino}-3-phenylpropanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-9,12-bis({[(2,2,2-trichloroethoxy)carbonyl]oxy})-6-oxatetracyclo[11.3.1.0^3,^1^0.0^4,^7]heptadec-13-en-2-yl benzoate
• Synonyms: [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-α-Hydroxy-β-[[[2-[(4-methoxyphenyl)methoxy]-1,1-dimethylethoxy]carbonyl]amino]benzenepropanoic Acid 12b-(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4,6-bis[[(2,2,2-trichloroethoxy)carbonyl]oxy]-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester

DATABASE IDS

• CAS Number: 154044-74-3

PROPERTIES

• Apperance: White Solid
• Solubility: Chloroform
• Solubility: Ethyl Acetate

DETAILS

Description (English)

An intermediate in partial synthesis of major human metabolites of Docetaxel (D494420), an antineoplastic.

REFERENCES

• Commercon, A., et al.: Tetrahedron, 50, 10289 (1994)