2,4-Dibenzyl-5-oxothiadiazolidine-3-thione

• Catalog No.: D417960
• CAS Number: 72966-20-2
• M. F.: C16H14N2OS2
• M. W.: 314.42516
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 2,4-dibenzyl-3-sulfanylidene-1,2,4-thiadiazolidin-5-one
• IUPAC Traditional name: 2,4-dibenzyl-3-sulfanylidene-1,2,4-thiadiazolidin-5-one
• Synonyms: 2,4-Bis(phenylmethyl)-3-thioxo-1,2,4-thiadiazolidin-5-one; GSK-3β Inhibitor III

DATABASE IDS

• CAS Number: 72966-20-2

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 104-107°C
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: Ethyl Acetate
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Glycogen Synthase Kinase-3β is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. An oxothiadiazolidine-3-thione analogue that acts as a non-ATP competitive inhibitor of GSK-3β ( IC50 =10uM).

REFERENCES

• Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)