Dexamethasone Phosphate

• Catalog No.: D298835
• CAS Number: 312-93-6
• M. F.: C22H30FO8P
• M. W.: 472.4409642

SYNONYMS

• IUPAC name: {2-[(1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-14-yl]-2-oxoethoxy}phosphonic acid
• IUPAC Traditional name: 2-[(1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-3,6-dien-14-yl]-2-oxoethoxyphosphonic acid
• Synonyms: Wymesone; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Phosphate; Betnelan Phosphate; Dexamethasone Orthophosphate; Micromethason; (11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione; Dexamethasone 21-Dihydrogen Phosphate; Dexamethasone 21-Phosphate

DATABASE IDS

• CAS Number: 312-93-6

DETAILS

Description (English)

A pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.

REFERENCES

• Kodelja, V., et al.: J. Immunol., 160, 1411 (1998)
• Metselaar, J., et al.: Arthritis Rheum., 48, 2059 (1998)
• Buttgereit, F., et al.: Arthritis Rheum., 50, 3408 (1998)
• Martinez, F., et al.: Front Biosci., 13, 453 (1998)