N-Desmethyl Topotecan

• Catalog No.: D294400
• CAS Number: 190710-79-3
• M. F.: C22H21N3O5
• M. W.: 407.41924

SYNONYMS

• IUPAC name: (19S)-19-ethyl-7,19-dihydroxy-8-[(methylamino)methyl]-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• IUPAC Traditional name: (19S)-19-ethyl-7,19-dihydroxy-8-[(methylamino)methyl]-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
• Synonyms: (4S)-4-Ethyl-4,9-dihydroxy-10-[(methylamino)methyl]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

DATABASE IDS

• CAS Number: 190710-79-3

DETAILS

Description (English)

A metabolite of Topotecan.

REFERENCES

• Herben, V., et al.: Anti-Cancer Drugs, 9, 411 (1998)
• Hsiang, Y., et al.: Cancer Res., 48, 1722 (1998)
• Hertzberg, R., et al.: J. Med. Chem., 32, 715 (1998)
• Beijnen, J., et al.: J. Pharm. Biomed. Anal., 8, 789 (1998)