N-Desmethyl-4-hydroxy Tamoxifen-d5 β-D-Glucuronide(E/Z Mixture)

• Catalog No.: D293862
• M. F.: C31H35NO8
• M. W.: 549.6115
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{4-[(1E)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenyl(^2H₅)but-1-en-1-yl]phenoxy}oxane-2-carboxylic acid
• IUPAC Traditional name: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{4-[(1E)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenyl(^2H₅)but-1-en-1-yl]phenoxy}oxane-2-carboxylic acid
• Synonyms: (E/Z)-Endoxifen Glucuronide; 4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenyl-d5 β-D-Glucopyranosiduronic Acid

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 228-232°C (dec.)
• Solubility: DMSO
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A novel active labelled metabolite of the anti-cancer drug Tamoxifen (T006000).

REFERENCES

• Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984)
• Leonessa, F., et al.: Cancer Res., 54, 441 (1984)
• Stearns, V., et al.: Lancet, 360, 1851 (1984)
• Rae, J., et al.: Pharmacogenetics, 13, 501 (1984)
• Zheng, Y., et al.: Drug Metab. Dispos., 35, 1942 (2007