N-Desmethyl Imatinib-d8

• Catalog No.: D292047
• M. F.: C28H29N7O
• M. W.: 479.57616

SYNONYMS

• IUPAC name: N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(2,2,3,3,5,5,6,6-^2H₈)piperazin-1-ylmethyl]benzamide
• IUPAC Traditional name: N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(2,2,3,3,5,5,6,6-^2H₈)piperazin-1-ylmethyl]benzamide
• Synonyms: N-Desmethyl Gleevec-d8

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 97-103°C
• Solubility: Chloroform
• Solubility: Dichloromethane

DETAILS

Description (English)

A deuterated metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL).

REFERENCES

• Schindler, T., et al.: Science, 289, 1938 (2000)
• Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2000)