N-Desmethyl-4-hydroxy Tamoxifen-d5 (1:1 E/Z Mixture)

• Catalog No.: D292044
• M. F.: C25H27NO2
• M. W.: 373.48738
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 4-[(1Z)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenyl(^2H₅)but-1-en-1-yl]phenol
• IUPAC Traditional name: 4-[(1Z)-1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenyl(^2H₅)but-1-en-1-yl]phenol
• Synonyms: (E/Z-Endoxifen-d5; 4OHNDtam-d5; 4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl-d5]phenol

PROPERTIES

• Apperance: Off-White to Light Pink Solid
• Melting Point: 74-78°C
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A novel active labelled metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. hu

REFERENCES

• Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984)
• Leonessa, F., et al.: Cancer Res., 54, 441 (1984)
• Stearns, V., et al.: Lancet, 360, 1851 (1984)
• Rae, J., et al.: Pharmacogenetics, 13, 501 (1984)