Desloratadine-d7 (major)

• Catalog No.: D290253
• M. F.: C19H19ClN2
• M. W.: 310.82056
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 13-chloro-2-[(2,2,3,5,6,6-^2H₆)piperidin-4-ylidene](5,9,10-^2H₃)-4-azatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,12,14-hexaene
• IUPAC Traditional name: 13-chloro-2-[(2,2,3,5,6,6-^2H₆)piperidin-4-ylidene](5,9,10-^2H₃)-4-azatricyclo[9.4.0.0^3,^8]pentadeca-1(11),3(8),4,6,12,14-hexaene
• Synonyms: Clarinex-d7; 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine-d7; Azomyr-d7; Neoclarityn-d7; Sch 34117-d7; NSC 675447-d7; Aerius-d7; Allex-d7; Descarboethoxyloratadine-d7; Opulis-d7

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 147-150°C
• Solubility: Chloroform
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Labelled Desloratadine (D290250). Nonsedating-type labelled histamine H1-receptor antagonist. An active labelled metabolite of Loratadine. Also inhibits generation and release of inflammatory mediators from basophils and mast cells.

REFERENCES

• Kreutner, W., et al.: Arzneimittel-Forsch., 50, 345 (2000)
• Salmun, L.M., et al.: Clin. Ther., 22, 613 (2000)
• Agrawal, D.K., et al.: Expert Opin. Invest. Drugs, 10, 547 (2000)