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Desloratadine

Catalog No. D290250 Name Toronto Research Chemicals
CAS Number 100643-71-8 Website http://www.trc-canada.com
M. F. C19H19ClN2 Telephone +1 (416) 665-9696
M. W. 310.82056 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage -20°C Freezer Chembase ID: 842

SYNONYMS

IUPAC name
13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaene
IUPAC Traditional name
clarinex
Synonyms
NSC 675447
Sch 34117
Aerius
Azomyr
Clarinex
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Allex
Neoclarityn
Opulis
Descarboethoxyloratadine

DATABASE IDS

CAS Number 100643-71-8

PROPERTIES

Certificate of Analysis Download
Apperance Off-White to Beige Solid
Melting Point 150-151°C
Solubility Chloroform
Solubility Ethyl Acetate
Solubility Hexane
MSDS Link Download
Storage Condition -20°C Freezer

DETAILS

Description (English)
Nonsedating-type histamine H1-receptor antagonist. An active metabolite of Loratadine. Also inhibits generation and release of inflammatory mediators from basophils and mast cells.An impurity arising in the synthesis of Rupatadine (R701650).

REFERENCES

  • Kreutner, W., et al.: Arzneimittel-Forsch., 50, 345 (2000)
  • Salmun, L.M., et al.: Clin. Ther., 22, 613 (2000)
  • Agrawal, D.K., et al.: Expert Opin. Invest. Drugs, 10, 547 (2000)