4-Desacetyl Vinblastine Methosulfate

• Catalog No.: D288440
• M. F.: C45H60N4O12S
• M. W.: 881.0425
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: methoxysulfonic acid methyl (9R,10S,11R,12R,19R)-12-ethyl-4-[(13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^4,^1^2.0^5,^1^0]nonadeca-4(12),5,7,9-tetraen-13-yl]-10,11-dihydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2,4,6,13-tetraene-10-carboxylate
• IUPAC Traditional name: methyl (9R,10S,11R,12R,19R)-12-ethyl-4-[(1R,13S,15R,17S)-17-ethyl-17-hydroxy-13-(methoxycarbonyl)-1,11-diazatetracyclo[13.3.1.0^4,^1^2.0^5,^1^0]nonadeca-4(12),5,7,9-tetraen-13-yl]-10,11-dihydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2,4,6,13-tetraene-10-carboxylate methyl sulfate
• Synonyms: O4-Deacetyl-vincaleukoblastine Methosulfate; Deacetylvinblastine Methosulfate; 4-Deacetylvinblastine Methosulfate

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: >300°C (dec.)
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A pro-drug of Vinblastine. Antitumor agent used for treatment of prostate cancer.

REFERENCES

• Raghavan, D., et al.: Eur. J. Cancer, 33, 566 (1997)
• Brady, S.F., et al.: J. Med. Chem., 45, 4706 (1997)