N-(Deoxyguanosin-8-yl)-2-amino-1-(methyl-d3)-6-phenylimidazo[4,5-β]pyridine

• Catalog No.: D239632
• CAS Number: 303173-39-9
• M. F.: C23H23N9O4
• M. W.: 489.48662
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-{[1-(^2H₃)methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl]amino}-6,9-dihydro-1H-purin-6-one
• IUPAC Traditional name: 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-{[1-(^2H₃)methyl-6-phenylimidazo[4,5-b]pyridin-2-yl]amino}-1H-purin-6-one
• Synonyms: dG-C8-PhIP-d3; 2'-Deoxy-8-[[1-(methyl-d3)-6-phenyl-1H-imidazo[4,5-b]pyridin-2-yl]amino]guanosine

DATABASE IDS

• CAS Number: 303173-39-9

PROPERTIES

• Apperance: Pale Yellow Solid
• Solubility: DMF
• Solubility: DMSO
• Storage Condition: Refrigerator

DETAILS

Description (English)

The deuterated DNA adduct formed from N-Hydroxy-PHIP. Mutagenic nucleotide incorporation and hindered translocation by a food carcinogen C8-dG adduct in Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4).

REFERENCES

• Frandsen, H., et al.: Carcinogenesis, 13, 4, 629 (1992)
• Lin, D., et al.: Chem. Res. Toxicol., 5, 691 (1992)
• Mizukami, S., et al.: Biochemistry, 45, 2772 (1992)