3'-Deoxy-3'-fluorothymidine-5'-monophosphate Disodium Salt

• Catalog No.: D235480
• M. F.: C10H12FN2Na2O7P
• M. W.: 368.1631842
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: disodium [(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl phosphate
• IUPAC Traditional name: disodium [(2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3H-pyrimidin-1-yl)oxolan-2-yl]methyl phosphate
• Synonyms: 2',3'-Dideoxy-3'-fluoro-5-methyluridine 5'-(Dihydrogen Phosphate) Disodium; 3'-Deoxy-3'-fluorothymidine Monophosphate Disodium; 3'-Deoxy-3'-fluoro-5'-thymidylic Acid Disodium; 3'-Fluoro-3'-deoxythymidine Monophosphate Disodium

PROPERTIES

• Apperance: White Solid
• Melting Point: 182-185°C
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

A thymidine-5'-O-monophosphate analogue as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

REFERENCES

• Jong, A., et al.: J. Biol. Chem., 259, 11052 ( 1984), Choi, Y., et al.: J. Med. Chem., 43, 2538 (2000)
• Stokstad, E., et al.: Science, 287, 2391 (2000)
• Li de La Sierra, I., et al.: J. Mol. Biol., 311, 87 (2000)