Denbufylline

• Catalog No.: D231400
• CAS Number: 57076-71-8
• M. F.: C16H24N4O3
• M. W.: 320.38676
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 1,3-dibutyl-7-(2-oxopropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
• IUPAC Traditional name: 1,3-dibutyl-7-(2-oxopropyl)purine-2,6-dione
• Synonyms: 1,3-Di-n-butyl-7-[2’-oxopropyl)xanthine; 1,3-Dibutyl-3,7-dihydro-7-(2-oxopropyl)-1H-purine-2,6-dione; BRL 30892

DATABASE IDS

• CAS Number: 57076-71-8

PROPERTIES

• Apperance: Off-White to Pale Beige Solid
• Melting Point: 98-100°C
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

A cell permeable xanthine derivatvie that acts as a selective inhibitor of phosphodiesterase IV (PDE IV). Possesses bronchodilatory properties. Displays negative inotropic effect by acting on a verapamil-sensitive site of the calcium channel in guinea p

REFERENCES

• Nicholson, C.D., et al.: Br. J. Pharmacol., 97, 889 (1989)
• Cortijo, J., et al.: Br. J. Pharmacol., 108, 562 (1989)
• Sanae, F., et al.: J. Pharmacol. Exp. Ther., 277, 54 (1989)
• Kumari, M., et al.: Br. J. Pharmacol., 121, 459 (1989)