3-Demethyl Thiocolchicine-d3

• Catalog No.: D231332
• M. F.: C21H23NO5S
• M. W.: 401.47602
• Storage: Refrigerator

SYNONYMS

• IUPAC name: N-[(10S)-5-hydroxy-3,4-dimethoxy-14-(methylsulfanyl)-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl](^2H₃)acetamide
• IUPAC Traditional name: N-[(10S)-5-hydroxy-3,4-dimethoxy-14-(methylsulfanyl)-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl](^2H₃)acetamide
• Synonyms: N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide-d3; NSC 361792-d3; 2-Demethylthio-colchicine-d3; 3-Demethylthiocolchicine-d3; 3-Desmethylthiocolchicine-d3; 3-O-Demethylthiocolchicine-d3

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: >246°C (dec.)
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

A Thiocolchicine metabolite, used in therapy as an antitunor, antiinflammatory and immunosuppressive agent.

REFERENCES

• Trellu, M., et al.: Fund. Clin. Pharmacol., 18, 493 (2004)
• Nakagawa-Goto, K., et al.: Bioorg. Med. Chem. Lett., 15, 235 (2004)
• Gelmi, M., et al.: J. Med. Chem., 50, 2245 (2004)