4'-Demethyl Homoharringtonine

• Catalog No.: D231150
• CAS Number: 98599-84-9
• M. F.: C28H37NO9
• M. W.: 531.59468

SYNONYMS

• IUPAC name: (3R)-3,7-dihydroxy-3-({[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.0^2,^6.0^6,^1^0.0^1^5,^1^9]icosa-1(20),4,13,15(19)-tetraen-3-yl]oxy}carbonyl)-7-methyloctanoic acid
• IUPAC Traditional name: (3R)-3,7-dihydroxy-3-({[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.0^2,^6.0^6,^1^0.0^1^5,^1^9]icosa-1(20),4,13,15(19)-tetraen-3-yl]oxy}carbonyl)-7-methyloctanoic acid
• Synonyms: 5'-Des-O-methylhomoharringtonine; Cephalotaxine 4-Hydrogen (2R)-2-Hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester)

DATABASE IDS

• CAS Number: 98599-84-9

DETAILS

Description (English)

A metabolite of Homoharringtonine, a cytotoxic component of the evergreen plant Cephalotaxus harringtonia.

REFERENCES

• Powell, R., et al.: J. Pharm. Sci., 61, 1227 (1972)
• Ohnuma, T., et al.: J. Clin. Oncol., 3, 604 (1972)
• Scudiero, D., et al.: Cancer Res., 48, 4827 (1972)
• Zhou, D., et al.: Bull. Cancer, 82, 987 (1972)
• Kantarjian, H., et al.: Cancer, 92, 1591 (1972)