Demethoxy Curcumin

• Catalog No.: D230815
• CAS Number: 22608-11-3
• M. F.: C20H18O5
• M. W.: 338.35392

SYNONYMS

• IUPAC name: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
• IUPAC Traditional name: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
• Synonyms: Desmethoxycurcumin; Curcumin II; (1E,6E)-1-(4-Hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; Monodemethoxycurcumin; (E,E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; 1-(4-Hydroxy-3-methoxyphenyl)-7-(p-hydroxyphenyl)-1,6-heptadiene-3,5-dione

DATABASE IDS

• CAS Number: 22608-11-3

DETAILS

Description (English)

The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through down-regulation of the transcriptional coactivator p300.

REFERENCES

• Ryu, M.J. et al.: Biochem. Biophys. Res. Comm., 377, 1304 (2008)
• Sandur, S.K. et al.: Carcinogenesis, 28, 1765 (2008)
• Huang, T. et al.: J. Agric. Food. Chem., 58, 10639 (2008)