DEMECOLCINE

• Catalog No.: D230785
• CAS Number: 477-30-5
• M. F.: C21H25NO5
• M. W.: 371.4269
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (10S)-3,4,5,14-tetramethoxy-10-(methylamino)tricyclo[9.5.0.0^2,^7]hexadeca-1(16),2,4,6,11,14-hexaen-13-one
• IUPAC Traditional name: colcemid
• Synonyms: (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo[a]heptalen-9(5H)-one; NSC 3096; Reichstein's F; Colcemid; Deacetylmethylcolchicine; Colchamin; Omain; Omaine; N-Desacetyl-N-methylcolchicine

DATABASE IDS

• CAS Number: 477-30-5

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: 73-75°C
• Solubility: Dichlormethane
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pa

REFERENCES

• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev